EP0057-201 Phase 2A Trial - Infusion appointment - 13 October 2021

 Because of the  undignified toilet requirements of this disease, I haven't promised to be in by 9am but have said I will try for 9:30. I manage 9:35 after a good run in on the bike with most roads reasonably clear. Maybe people are still chary of driving with petrol a bit uncertain still in London. 

It's still leaking here even though it's not raining today. As well as a group of yellow buckets catching ceiling drips, there's a collection of cloths under a window.

Vitals and 12-lead ECG has to be done before the pre meds and infusion. They also do a Covid swab, which as things transpire is probably a good thing - see next entry.

Because EP0057 is tough on the bladder and associated with cystitis and bladder infections, there are even more fluids to be taken on board than usual. In this order:

iv hydration with saline, oral ondansetron and ranitidine, iv dexamethasone and chlorpheniramine, iv glucose, EP0057, more iv glucose, more iv saline hydration. This is all associated with multiple visits to the loo for a pee as you might expect, drip trolley rolling along too.

The Charge Nurse in charge has been doing a lot of sums - height, weight, calculation of body surface area - 1.7 sq m, so not worth flaying me for leather - timings as this stuff only has a shelf life of about four hours after being made up.

Another ECG after the EP0057, three more blood lettings during four hours of post-infusion observation - I'm going to have more than five venepuncture sites as the research samples can't be taken from the cannula where the various fluids are going in, and some veins aren't productive enough.

So another long day - 9:35 to 18:45, but then a lift home with the bike in the back of the car. I felt like I could have ridden home - slowly - but that was probably the dexamethasone talking. It certainly talked in the car. 😀I'm finishing this off on Friday 15th and the dexamethasone is still talking. 😄